In industrial and laboratory filtration, the pursuit of better solutions never ends—especially those that are compact, reliable, and long-lasting. Is there a technology that delivers all three?

The answer lies in PES hollow fiber filtration. This powerful technology is at the heart of countless critical processes—from producing life-saving medicines to purifying process water. What makes it so special? Three core strengths make our PES hollow fiber filters stand out: a compact design, reliable performance, and long-lasting durability.

The Design: What Are PES Hollow Fiber Filters?

First, the basics. PES stands for polyethersulfone—a high-performance polymer known for its robustness and stability. This material is formed into hundreds of tiny, straw-like fibers bundled into a single module. Each fiber is “hollow”—its walls are lined with ultra-fine pores.

During filtration, fluid flows inside the fibers. Under pressure, the desired liquid (permeate) passes through the porous walls, while unwanted particles, cells, or contaminants are retained and flushed away. This process, known as cross-flow filtration, is highly efficient and gentle—making it ideal for sensitive applications like bioprocessing.

1. Compact Design: Maximum Filtration Area, Minimum Space

The most striking advantage of hollow fiber design is its incredible packing density. Imagine the internal surface area of a single straw—then shrink thousands of them into a cylindrical module the size of your forearm. That’s the power of hollow fiber technology: maximum filtration area in a minimal footprint.

CleaSep™ PES hollow fiber filters are available in 17 different sizes—suitable for everything from R&D to full-scale production. Their space-saving design makes them ideal for lab environments and production facilities where space is limited.

2. Reliable Performance: Consistent Results, Batch After Batch

• In critical applications, performance must be predictable and consistent. CleaSep™ filters deliver:
• Stable filtration efficiency with narrow pore size distribution
• Low protein binding and minimal fouling for higher product recovery
• Excellent scalability from lab to production with reliable linear performance
• Broad chemical compatibility with various buffers and biologics

This reliable performance makes PES hollow fiber filters a preferred choice in industries like biopharma and vaccine production.

3. Long-Lasting Durability: Built to Endure

The true cost of a filter isn’t just its price—it’s the total cost of ownership, including maintenance, downtime, and replacement frequency. CleaSep™ PES hollow fiber filters are engineered to last:

• High chemical resistance: compatible with 1N NaOH at 80°C
• Thermal stability: suitable for SIP (Steam-in-Place) sterilization
• Mechanical strength: tolerates high shear rates and process disturbances
• Easy cleaning: reduces downtime and extends service life
  These features result in a truly long-lasting filtration solution that lowers operational costs over time.

Applications of PES Hollow Fiber Filtration

The combination of compact design, reliability, and durability makes PES hollow fiber filters extremely versatile. Key applications include:

• Purification and concentration of recombinant proteins/antibodies
• Vaccine dialysis and virus concentration
• Cell harvest and clarification of fermentation broth
• Water and buffer purification in industrial processes

Choose Membrane Solutions for Excellence in Filtration

Selecting the right filtration technology impacts your efficiency, output, and bottom line. At Membrane Solutions, we don’t just sell filters—we deliver engineered solutions backed by expertise and quality.
Our CleaSep™ PES hollow fiber modules are designed to balance compact size, reliable operation, and long-lasting performance. We are committed to providing advanced technology that makes your filtration process fail-safe and efficient.
Ready to optimize your process? Explore our full range of high-performance PES hollow fiber filters, or contact us to find the best solution for your application.