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UltraMem? Nuggets TFF Cassettes
Membrane Solutions can provide tangential filtration solutions, the UltraMem Nuggets TFF cassettes, for our customers, to fulfill the needs in bio-pharmaceutical applications. UltraMem Nuggets cassettes are composed of UltraMem high performance UF membranes. It is a high performance tangential flow filter product with safety, convenience and cost efficiency for bio-pharm and bio-tech process.Typical applications of UltraMem Nugget cassettes include but no limited to the concentration and separation of monoclonal antibiotics, recombinant protein drugs, virus-vectors, vaccines, plasmid, mRNA LNP, particulate dispersions, cell culture clarications, buffer exchange, etc.
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Features
- Fast and reliable linear amplication from the lab to production scale
- Robust and reliable design enables UltraMem Nuggets to withstand high pressure and temperature (max 5bar@40℃)
- Easy to operate, fast installation and cleaning, ensure reliable yield; <10% ux decline after 200 hrs caustic wash; Max 210g/L concentration can be achieved
- Broad chemical compatibility
- Multiple MWCOs and/or pore size to choose, combined with multiple process area, and membrane materials, meet your demands
Applications
- Concentration of biomolecules (recombinant proteins, monoclonal antibodies, viruses, etc.)
- Dialysis, desalination, and buffer replacement
- Separation and purification
- Remove endotoxins
- Except for macromolecules, etc
Technical Parameters
| Membrane Type | Modifed PES | Regenerated Cellulose | |
| Filtration Type | UF | MF | UF |
| MWCO | 5/8/10/30/50/70/100/300/500 kD | 0.1/0.2/0.45 μm | 1/2/3/10/30/100/300 kD |
| Flow Rate | Fast | Medium | |
| Static Protein Adsorption | Low | Very Low | |
| pH Range | 1-14 | 2-13 | |
| Recommendations | Fast process of protein solutions; harsh process and cleaning conditions |
Viscous and high conc.%liquid,where high recovery is demanded |
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| Materials of Construction | Housing | Silicone (Soft) | Resin(Rigid) | |
| Membrane | Modifed PES with nonwoven support | Regenerated Cellulose with nonwoven support | ||
| Channel/Fleece | Polypropylene | Polypropylene | ||
| Preservation Liquid | 20%glycerol+0.05 M NaOH | 20%glycerol+0.05 M NaOH | ||
| Operating | Housing | Silicone (Soft) | Resin(Rigid) | |
| Maximum Inlet Pressure | 5.5bar@25℃;4 bar@40℃ | 5.5 bar@25℃;5 bar@40℃ | ||
| Operating pH Range | 1-14 for PES membrane,2-13 for RC membrane | |||
| Dimensions | Filtration Area | Silicone (Soft) | Resin(Rigid) | Processing Volumes |
| 100 cm² | L/W/H:205×56×2 | L/W/H:205×56×4 | 100-1000 ml | |
| 0.1 m² | L/W/H:205×56×16 | L/W/H:205×56×16 | 0.2-10L | |
| 0.5 m² | L/W/H:205×173×17 | L/W/H:205×178×16 | >2L | |
| 2.5 m² | L/W/H:205×173×88 | L/W/H:205×178×72 | >10L | |
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